have shown that tumor IFP can be decreased by placing artificial lymphatics in tumors, supporting the notion that a lack of functional lymphatics contributes to increased IFP. Boucher and Jain reported that, in tumors, the microvascular pressure (MVP) and IFP are in equilibrium because of increased vascular permeability, suggesting that MVP is the driving force for elevated IFP. IFP can be elevated by abnormal (fast‐growing, leaky, sometimes dysfunctional) tumor blood vessels, high tumor cellularity and a lack of functional lymphatics. INTRODUCTION The effective delivery of therapeutic drugs to the core of tumors is often impeded by physiological barriers, such as the interstitial fluid pressure (IFP). Sigmund, Eric E.Ībbreviations used AAV apparent avascular voxel ADC apparent diffusion coefficient AVV apparent vascular voxel BIC Bayesian information criterion DCE dynamic contrast enhanced DWI diffusion‐weighted imaging Gd‐DTPA gadolinium‐diethylenetriaminepentaacetic acid IFP interstitial fluid pressure IQR interquartile range IVIM intravoxel incoherent motion MVP microvascular pressure RARE rapid acquisition with relaxation enhancement ROI region of interest RSS residual sum of squares SNR signal‐to‐noise ratio VEGF vascular endothelial growth factor WIN wick‐in‐needle. Moy, Linda Formenti, Silvia Schneider, Robert J. Kim, Sungheon Decarlo, Lindsey Cho, Gene Y. Interstitial fluid pressure correlates with intravoxel incoherent motion imaging metrics in a mouse mammary carcinoma model Interstitial fluid pressure correlates with intravoxel incoherent motion imaging metrics in a.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |